Best Protein Powders for People on GLP-1s

The best protein powder on a GLP-1 medication packs a lot of protein into a small, easy-to-drink serving, with little sugar and nothing that upsets your stomach. Our top pick is Transparent Labs Grass-Fed Whey Isolate, and if a creamy shake feels too heavy, Myprotein Clear Whey Isolate drinks more like juice. Both make it easier to reach the 80–120 g of protein a day experts recommend while you're losing weight.

New to the topic? Start with our guide to protein on GLP-1 medications, which explains why protein and strength training matter so much on these drugs.

Our Picks at a Glance

Figures are per serving and vary slightly by flavor. Check the label on the flavor you buy. We don't show prices because they change often.

What Matters on a GLP-1

GLP-1 medications cut your appetite and can cause nausea, fullness and constipation. That changes what makes a good protein powder:

• Protein density. You want as much protein as possible in as few calories and as little volume as possible. Isolates win here.
• Easy on the stomach. Whey isolate has very little lactose. Clear proteins are thin and light. Large amounts of sugar alcohols or fiber can make bloating worse for some people.
• Low sugar. You want the calories you do eat to come from protein.
• Third-party testing. Certification from NSF or Informed Choice confirms the protein on the label is really there. We checked NSF's certified product database on November 12, 2026.

Our guide on how to read a supplement label explains how to check any powder yourself.

1. Transparent Labs Grass-Fed Whey Isolate: Best Overall

Transparent Labs packs about 28 g of protein into roughly 120–130 calories, with under 1 g of sugar. It's NSF Certified for Sport, and it's sweetened with stevia rather than sugar or sucralose. It's our top-rated protein powder overall, and its high protein per scoop makes it the most efficient way to hit your target when you can't eat much.

Good to know: it's one of the pricier options. If a full scoop feels like too much at once, make a smaller shake and drink the rest later.

2. Momentous Essential Whey: Smallest, Lightest Serving

Momentous Essential is a grass-fed whey isolate with 20 g of protein in 90 calories, from a smaller scoop than most. It's NSF Certified for Sport and includes a digestive enzyme blend. The unflavored version is just whey, so you can stir it into Greek yogurt, oatmeal or coffee without changing the taste much.

Good to know: at 20 g per scoop, you get less protein per serving than Transparent Labs, but the smaller serving can be easier to finish.

3. Myprotein Clear Whey Isolate: When Shakes Feel Too Heavy

Clear whey is whey isolate processed to mix into a thin, juice-like drink instead of a milky shake. Many people on GLP-1s find it far easier to sip when they feel full or a bit nauseous. Myprotein's version has 20 g of protein in under 90 calories, with no fat and almost no sugar, and the brand says it's Informed Choice certified.

Good to know: mix it with cold water and let the foam settle for a minute before drinking. It tastes best very cold.

4. Isopure Zero Carb: Zero Carbs, Widely Available

Isopure Zero Carb is a whey isolate with 25 g of protein, zero carbs and about 100–110 calories per scoop. It's easy to find and a good choice if you're watching carbs closely, for example if you also have type 2 diabetes.

Good to know: it isn't NSF or Informed certified. Isopure is a long-established brand, but if testing matters most to you, choose one of the certified picks above.

5. Orgain Organic Protein: Best Plant-Based

If dairy doesn't agree with you, Orgain Organic Protein is a widely available plant blend of pea, brown rice and chia, with 21 g of protein and 150 calories per two-scoop serving and almost no sugar. It also has about 7 g of fiber, which may help with the constipation some people get on GLP-1s.

Good to know: it's higher in calories and volume than the whey isolates, and it's sweetened partly with erythritol, a sugar alcohol that can cause bloating in some people. Start with a half serving to see how you feel. For more vegan options, see plant protein vs whey.

Tips for Drinking Protein Shakes on a GLP-1

• Sip slowly. Drinking a shake over 20–30 minutes is easier than downing it at once, especially if you feel full or nauseous.
• Make it smaller. Use half a scoop in less liquid, and have a second small shake later.
• Try it cold. Very cold shakes and clear proteins are usually easier on a sensitive stomach.
• Mix it into food. Unflavored whey stirs into Greek yogurt, oatmeal or soup.
• Don't replace every meal. A shake helps you hit your target, but real food gives you fiber and nutrients a powder can't. The joint advisory on GLP-1 nutrition recommends protein-rich whole foods first, with shakes to fill the gap.

FAQ

What's the best protein powder for Ozempic or Wegovy?

One that's high in protein, low in sugar and easy for you to drink. Transparent Labs Grass-Fed Whey Isolate is our top pick for its 28 g of protein per scoop and NSF certification. If creamy shakes feel too heavy, try a clear whey.

How much protein powder should I have a day on a GLP-1?

It depends on how much protein you get from food. Most people aim for 80–120 g of protein a day in total. One or two shakes can cover 20–55 g of that. See protein on GLP-1 medications for how to work out your target.

Is whey or plant protein better on a GLP-1?

Whey isolate is usually more protein-dense and easier to drink, so it's the better default. Choose a plant protein if you're vegan or dairy upsets your stomach.

Are protein shakes safe on a GLP-1?

For most people, yes. Check with your prescriber if you have kidney disease, and start with smaller servings if you have nausea. More in is protein powder safe?

What is clear whey?

Clear whey is whey protein isolate that's been processed so it mixes into a thin, fruit-flavored drink instead of a creamy shake. It has a similar amount of protein but feels much lighter, which many people find easier when their appetite is low.

The Bottom Line

On a GLP-1 medication, the best protein powder is the one you'll actually drink. Transparent Labs Grass-Fed Whey Isolate is our top pick for its protein per scoop and NSF certification. Choose Momentous for a smaller serving, Myprotein Clear Whey if shakes feel too heavy, Isopure if you want zero carbs, or Orgain if you need plant-based. For more options, see our ranking of the cleanest protein powders.